![Targeting the Sphingosine Kinase/Sphingosine 1‐Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases - Schwalm - 2014 - Basic & Clinical Pharmacology & Toxicology - Wiley Online Library Targeting the Sphingosine Kinase/Sphingosine 1‐Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases - Schwalm - 2014 - Basic & Clinical Pharmacology & Toxicology - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/6604fba4-b5e3-4d89-a060-7dc030d30acb/bcpt12103-fig-0001-m.jpg)
Targeting the Sphingosine Kinase/Sphingosine 1‐Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases - Schwalm - 2014 - Basic & Clinical Pharmacology & Toxicology - Wiley Online Library
![Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects | Arthritis Research & Therapy | Full Text Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects | Arthritis Research & Therapy | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Far2711/MediaObjects/13075_2009_Article_2551_Fig1_HTML.jpg)
Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects | Arthritis Research & Therapy | Full Text
![Chemical structures of sphingosine 1-phosphate, fingolimod, siponimod... | Download Scientific Diagram Chemical structures of sphingosine 1-phosphate, fingolimod, siponimod... | Download Scientific Diagram](https://www.researchgate.net/publication/346845716/figure/fig1/AS:1066406057607170@1631262425948/Chemical-structures-of-sphingosine-1-phosphate-fingolimod-siponimod-and-cenerimod.png)
Chemical structures of sphingosine 1-phosphate, fingolimod, siponimod... | Download Scientific Diagram
![Trends in the Use of Sphingosine 1 Phosphate in Age-Related Diseases: A Scientometric Research Study (1992-2020) Trends in the Use of Sphingosine 1 Phosphate in Age-Related Diseases: A Scientometric Research Study (1992-2020)](https://static.hindawi.com/articles/jdr/volume-2021/4932974/figures/4932974.fig.002b.jpg)
Trends in the Use of Sphingosine 1 Phosphate in Age-Related Diseases: A Scientometric Research Study (1992-2020)
![Sphingosine‐1‐phosphate receptor modulators in stroke treatment - Zhang - 2022 - Journal of Neurochemistry - Wiley Online Library Sphingosine‐1‐phosphate receptor modulators in stroke treatment - Zhang - 2022 - Journal of Neurochemistry - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/521b823e-b413-4727-81a7-023255248763/jnc15685-fig-0002-m.png)
Sphingosine‐1‐phosphate receptor modulators in stroke treatment - Zhang - 2022 - Journal of Neurochemistry - Wiley Online Library
![Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0008874920304032-gr4.jpg)
Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect
![Trends in the Use of Sphingosine 1 Phosphate in Age-Related Diseases: A Scientometric Research Study (1992-2020) Trends in the Use of Sphingosine 1 Phosphate in Age-Related Diseases: A Scientometric Research Study (1992-2020)](https://static.hindawi.com/articles/jdr/volume-2021/4932974/figures/4932974.fig.007.jpg)
Trends in the Use of Sphingosine 1 Phosphate in Age-Related Diseases: A Scientometric Research Study (1992-2020)
![Cells | Free Full-Text | The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives Cells | Free Full-Text | The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives](https://pub.mdpi-res.com/cells/cells-09-01515/article_deploy/html/images/cells-09-01515-g001.png?1594110377)
Cells | Free Full-Text | The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives
![Preclinical to clinical translation of cenerimod, a novel S1P1 receptor modulator, in systemic lupus erythematosus | RMD Open Preclinical to clinical translation of cenerimod, a novel S1P1 receptor modulator, in systemic lupus erythematosus | RMD Open](https://rmdopen.bmj.com/content/rmdopen/6/2/e001261/F6.large.jpg)
Preclinical to clinical translation of cenerimod, a novel S1P1 receptor modulator, in systemic lupus erythematosus | RMD Open
Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P1) Agonists and Future Perspectives | Journal of Medicinal Chemistry
![PDF) Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives PDF) Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives](https://i1.rgstatic.net/publication/361623897_Sphingosine-1-Phosphate_S1P_and_S1P_Signaling_Pathway_Modulators_from_Current_Insights_to_Future_Perspectives/links/62c889ce00d0b4511040dda7/largepreview.png)
PDF) Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives
![Chemical structures of sphingosine 1-phosphate, fingolimod, siponimod... | Download Scientific Diagram Chemical structures of sphingosine 1-phosphate, fingolimod, siponimod... | Download Scientific Diagram](https://www.researchgate.net/profile/Bisera-Stepanovska-Tanturovska/publication/346845716/figure/fig1/AS:1066406057607170@1631262425948/Chemical-structures-of-sphingosine-1-phosphate-fingolimod-siponimod-and-cenerimod_Q320.jpg)
Chemical structures of sphingosine 1-phosphate, fingolimod, siponimod... | Download Scientific Diagram
![IJMS | Free Full-Text | A Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury IJMS | Free Full-Text | A Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury](https://www.mdpi.com/ijms/ijms-23-04010/article_deploy/html/images/ijms-23-04010-g001.png)
IJMS | Free Full-Text | A Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury
![Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 | Nature Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 | Nature](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fnature02284/MediaObjects/41586_2004_Article_BFnature02284_Fig5_HTML.jpg)
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 | Nature
![IJMS | Free Full-Text | Targeting S1PRs as a Therapeutic Strategy for Inflammatory Bone Loss Diseases—Beyond Regulating S1P Signaling IJMS | Free Full-Text | Targeting S1PRs as a Therapeutic Strategy for Inflammatory Bone Loss Diseases—Beyond Regulating S1P Signaling](https://www.mdpi.com/ijms/ijms-22-04411/article_deploy/html/images/ijms-22-04411-g001-550.jpg)
IJMS | Free Full-Text | Targeting S1PRs as a Therapeutic Strategy for Inflammatory Bone Loss Diseases—Beyond Regulating S1P Signaling
![Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0008874920304032-gr2.jpg)
Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect
![Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0008874920304032-gr5.jpg)
Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect
![IJMS | Free Full-Text | In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1P1) Expression and Mediated Migration of Primary Human T and B Cells in the Context of Cenerimod, a Novel, IJMS | Free Full-Text | In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1P1) Expression and Mediated Migration of Primary Human T and B Cells in the Context of Cenerimod, a Novel,](https://www.mdpi.com/ijms/ijms-23-01191/article_deploy/html/images/ijms-23-01191-g001.png)
IJMS | Free Full-Text | In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1P1) Expression and Mediated Migration of Primary Human T and B Cells in the Context of Cenerimod, a Novel,
![Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis ... Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis ...](https://pubs.acs.org/cms/10.1021/acs.jmedchem.1c00138/asset/images/large/jm1c00138_0002.jpeg)
Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis ...
![Cenerimod, a selective S1P1 receptor modulator, improves organ-specific disease outcomes in animal models of Sjögren's syndrome | Arthritis Research & Therapy | Full Text Cenerimod, a selective S1P1 receptor modulator, improves organ-specific disease outcomes in animal models of Sjögren's syndrome | Arthritis Research & Therapy | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13075-021-02673-x/MediaObjects/13075_2021_2673_Fig4_HTML.png)
Cenerimod, a selective S1P1 receptor modulator, improves organ-specific disease outcomes in animal models of Sjögren's syndrome | Arthritis Research & Therapy | Full Text
![Potent anti‐inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL‐S1P and their impairment in coronary artery disease due to lower HDL‐S1P: a new aspect of HDL dysfunction and its Potent anti‐inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL‐S1P and their impairment in coronary artery disease due to lower HDL‐S1P: a new aspect of HDL dysfunction and its](https://faseb.onlinelibrary.wiley.com/cms/asset/54e68531-3c92-4427-bb54-2b36065e024d/fsb2fj201801245r-fig-0009-m.jpg)
Potent anti‐inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL‐S1P and their impairment in coronary artery disease due to lower HDL‐S1P: a new aspect of HDL dysfunction and its
![Whole Blood and Plasma-Based Lipid Profiling Reveals Distinctive Metabolic Changes in Systemic Lupus Erythematosus and Systemic Sclerosis | Journal of Proteome Research Whole Blood and Plasma-Based Lipid Profiling Reveals Distinctive Metabolic Changes in Systemic Lupus Erythematosus and Systemic Sclerosis | Journal of Proteome Research](https://pubs.acs.org/cms/10.1021/acs.jproteome.3c00321/asset/images/large/pr3c00321_0008.jpeg)
Whole Blood and Plasma-Based Lipid Profiling Reveals Distinctive Metabolic Changes in Systemic Lupus Erythematosus and Systemic Sclerosis | Journal of Proteome Research
![Cytokine‐Induced and Stretch‐Induced Sphingosine 1‐Phosphate Production by Enthesis Cells Could Favor Abnormal Ossification in Spondyloarthritis - El Jamal - 2019 - Journal of Bone and Mineral Research - Wiley Online Library Cytokine‐Induced and Stretch‐Induced Sphingosine 1‐Phosphate Production by Enthesis Cells Could Favor Abnormal Ossification in Spondyloarthritis - El Jamal - 2019 - Journal of Bone and Mineral Research - Wiley Online Library](https://asbmr.onlinelibrary.wiley.com/cms/asset/44c531af-ffc3-4afe-8915-9ff47d5d7d31/jbmr3844-fig-0009-m.jpg)
Cytokine‐Induced and Stretch‐Induced Sphingosine 1‐Phosphate Production by Enthesis Cells Could Favor Abnormal Ossification in Spondyloarthritis - El Jamal - 2019 - Journal of Bone and Mineral Research - Wiley Online Library
![Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 | Nature Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 | Nature](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnature02284/MediaObjects/41586_2004_Article_BFnature02284_Fig1_HTML.jpg)
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 | Nature
![Cells | Free Full-Text | Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives Cells | Free Full-Text | Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives](https://www.mdpi.com/cells/cells-11-02058/article_deploy/html/images/cells-11-02058-g003-550.jpg)
Cells | Free Full-Text | Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives
![Biomedicines | Free Full-Text | Sphingosine-1-Phosphate: Its Pharmacological Regulation and the Treatment of Multiple Sclerosis: A Review Article Biomedicines | Free Full-Text | Sphingosine-1-Phosphate: Its Pharmacological Regulation and the Treatment of Multiple Sclerosis: A Review Article](https://www.mdpi.com/biomedicines/biomedicines-08-00227/article_deploy/html/images/biomedicines-08-00227-g004-550.jpg)
Biomedicines | Free Full-Text | Sphingosine-1-Phosphate: Its Pharmacological Regulation and the Treatment of Multiple Sclerosis: A Review Article
![Frontiers | Competitive Binding of Ozanimod and Other Sphingosine 1-Phosphate Receptor Modulators at Receptor Subtypes 1 and 5 Frontiers | Competitive Binding of Ozanimod and Other Sphingosine 1-Phosphate Receptor Modulators at Receptor Subtypes 1 and 5](https://www.frontiersin.org/files/MyHome%20Article%20Library/892097/892097_Thumb_400.jpg)
Frontiers | Competitive Binding of Ozanimod and Other Sphingosine 1-Phosphate Receptor Modulators at Receptor Subtypes 1 and 5
![Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0008874920304032-gr6.jpg)
Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect
![Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells - ScienceDirect Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S138819811300200X-gr10.jpg)
Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells - ScienceDirect
![IJMS | Free Full-Text | Immune System and Brain/Intestinal Barrier Functions in Psychiatric Diseases: Is Sphingosine-1-Phosphate at the Helm? IJMS | Free Full-Text | Immune System and Brain/Intestinal Barrier Functions in Psychiatric Diseases: Is Sphingosine-1-Phosphate at the Helm?](https://pub.mdpi-res.com/ijms/ijms-24-12634/article_deploy/html/images/ijms-24-12634-ag.png?1691714002)
IJMS | Free Full-Text | Immune System and Brain/Intestinal Barrier Functions in Psychiatric Diseases: Is Sphingosine-1-Phosphate at the Helm?
![PDF) 6 Efficacy of cenerimod, a selective S1P1 receptor modulator, in the MRL/lpr mouse model of systemic lupus erythematosus PDF) 6 Efficacy of cenerimod, a selective S1P1 receptor modulator, in the MRL/lpr mouse model of systemic lupus erythematosus](https://i1.rgstatic.net/publication/332386471_6_Efficacy_of_cenerimod_a_selective_S1P1_receptor_modulator_in_the_MRLlpr_mouse_model_of_systemic_lupus_erythematosus/links/600dd45592851c13fe355f72/largepreview.png)
PDF) 6 Efficacy of cenerimod, a selective S1P1 receptor modulator, in the MRL/lpr mouse model of systemic lupus erythematosus
![Molecules | Free Full-Text | Dysregulation of Cell Death and Its Epigenetic Mechanisms in Systemic Lupus Erythematosus Molecules | Free Full-Text | Dysregulation of Cell Death and Its Epigenetic Mechanisms in Systemic Lupus Erythematosus](https://pub.mdpi-res.com/molecules/molecules-22-00030/article_deploy/html/images/molecules-22-00030-g001.png?1569159496)
Molecules | Free Full-Text | Dysregulation of Cell Death and Its Epigenetic Mechanisms in Systemic Lupus Erythematosus
![Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0008874920304032-gr3.jpg)
Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect
![IJMS | Free Full-Text | Sphingosine 1-Phosphate as Essential Signaling Molecule in Inflammatory Skin Diseases IJMS | Free Full-Text | Sphingosine 1-Phosphate as Essential Signaling Molecule in Inflammatory Skin Diseases](https://www.mdpi.com/ijms/ijms-24-01456/article_deploy/html/images/ijms-24-01456-g003-550.jpg)
IJMS | Free Full-Text | Sphingosine 1-Phosphate as Essential Signaling Molecule in Inflammatory Skin Diseases
![Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases - ScienceDirect Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1043661818320395-gr1.jpg)
Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases - ScienceDirect
![IJMS | Free Full-Text | A Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury IJMS | Free Full-Text | A Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury](https://www.mdpi.com/ijms/ijms-23-04010/article_deploy/html/images/ijms-23-04010-g007-550.jpg)
IJMS | Free Full-Text | A Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury
![Preclinical to clinical translation of cenerimod, a novel S1P1 receptor modulator, in systemic lupus erythematosus | RMD Open Preclinical to clinical translation of cenerimod, a novel S1P1 receptor modulator, in systemic lupus erythematosus | RMD Open](https://rmdopen.bmj.com/content/rmdopen/6/2/e001261/F1.large.jpg)
Preclinical to clinical translation of cenerimod, a novel S1P1 receptor modulator, in systemic lupus erythematosus | RMD Open
![Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0008874920304032-gr1.jpg)
Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)/S1P receptors during chronic liver injury - ScienceDirect
![Cells | Free Full-Text | Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives Cells | Free Full-Text | Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives](https://pub.mdpi-res.com/cells/cells-11-02058/article_deploy/html/images/cells-11-02058-g001-550.jpg?1657162131)